Tod Machover of MIT’s Media Lab is devoted to extending musical expression for everyone — from virtuosi to amateurs, and in the most diverse forms — from opera to videogames (Guitar Hero grew out of his group).
At TED2008, he talked about what’s coming next, from new tools for music creativity to the world’s first robotic [...]

Activision announced today that it is taking its Guitar Hero franchise into new territory, with Guitar Hero World Tour:
Guitar Hero World Tour will marry Guitar Hero’s guitar gameplay, with a cooperative band experience that combines the most advanced wireless instruments with revolutionary new online and offline gameplay modes. The game will feature a slick newly [...]

The MIDIator is a new synth DIY project that turns a PS2 controller into a MIDI controller.
The current firmware supports remapping of the buttons to different notes or controllers. It’s [...]

Slapyak has an interesting tutorial on creating a Guitar Hero MIDI controller.
With the current version you can:

play 2 octaves of an 8 note scale at a time
change the starting note anywhere in the range of a regular keyboard
change octaves
change keys
change tonal modes (Ionian, Mixolydian, Lydian, Dorian, Aeolian, Phrygian, Locrian)
change [...]

Here’s something out of left field:
Shredz64 is a modern day game for the Commodore 64 that makes use of the Playstation guitar controller hooked through the PSX64 interface.
Its design is modeled after the popular “Guitar Hero” series, geared toward the ability to play along to your favorite C64 music on the guitar. Correctly played notes [...]

DJ Tech Tools’ Ean Golden posted this fun video of himself DJing with a Guitar Hero Controller:
Arcade buttons are cool but taking a plastic guitar into the crowd and taping away a solo is some next level fun. In the past 5 years I have experimented with just about every piece of midi gear out [...]

The Scratch Blaster is a prototype controller combining a portable turntable and a Guitar Hero controller.
Cool, but I’d rather see a real electronic music game!

A free video game for Mac & Windows, Synthesia, is generating a lot of buzz as a sort of Guitar Hero for keyboard players.
Synthesia loosely follows the Guitar Hero format — music tracks appear visually on screen, and your challenge is to play the correct notes on a keyboard. Unlike Guitar Hero, however, Synthesia [...]