AudiOdyssey is a free experimental computer game designed to be accessible to both the visually impaired community and mainstream gamers.
AudiOdyssey was developed with four research goals:

The visually-impaired and the sighted can enjoy the same level and quality of gameplay
Navigate game’s menus with ease and efficiency approaching that of conventional user-interfaces (UIs)
Create a fun [...]

Remain Calm has put together a list of its top 24 music apps for the Nintendo DS:

bliptracker - a drum machine & sequencer
dsmcu - MCU-compatible mix controller
Protein[DS] - sample looper, scratcher, glitcher
nitrotracker
kaosDS - converts touchscreen data into midi over wifi
sampling keyboard
dstep v2 - a visual sequencer
glitchDS - a cellular automation sequencer
repeaterDS - stuttering sample player
midipad [...]

This video demos WiiAmbient, a free new ambient music program for the Wii from Gleetchplug.
It’s not available yet - but it looks like it will be very cool.

BoxBeat is a prototype toy that turns the surface of your desk into a beat making instrument.
It uses contact microphones to detect different sounds from the desk surface, and a simple software patch to trigger audio samples.
“I often find myself tapping away on my desk, and this is a fun and simple way to experiment [...]

This episode of the 1Up show - an online video game show - features a look at the new Korg DS-10 synthesizer, which runs on the Nintendo DS platform.

Tony Amendolare at ElectroKraft has created a unique new music controller for the NES, the Sonic DrumAxe.
Tony’s always coming up with unusual instruments (see our previous ElectroKraft coverage), and the Sonic DrumAxe is no exception.
The Sonic DrumAxe is a controller that connects to the Nintendo NES video game system. Used with the Super Synth Drums [...]

Need an excuse to blow a bunch of money on WII stuff?
Here you go:
BodySurf is a script for GlovePIE that rigs up the Wii Balance Board to play Audiosurf, the music game that lets you ride the boogie.
It is full-featured, with a strong focus on player immersion and ease of user interface. The controls are [...]

Last year, we brought you some great video of game creator Will Wright and Brian Eno on generative systems.
Here’s the whole enchilada - their Long Now discussion of Spore and generative music and gaming.
They touch on all sorts of topics, but it includes great discussions of generative processes and ambient music, fractals, compression [...]

Joey Nariano [animal-style] demonstrates his GBC Gameboy Foot Controller.

OT: Electronic Arts has introduced the latest in its series of Sims games - The Sims DJ.
The Sims DJ is a $5 iPod Game for third-generation iPod nanos, fifth-generation iPods, and iPod classics.
Description:
The Sims DJ lets you create a Sim character, play, mix and scratch songs from your iTunes library to make crowds of Sims dance, and move [...]

From the because it was there category:
Sebastian Tomczak posted this video of a working prototype version of an interface that controls the sound chip inside of a (real) Sega Master System using MIDI data. 

Activision announced today that it is taking its Guitar Hero franchise into new territory, with Guitar Hero World Tour:
Guitar Hero World Tour will marry Guitar Hero’s guitar gameplay, with a cooperative band experience that combines the most advanced wireless instruments with revolutionary new online and offline gameplay modes. The game will feature a slick newly [...]

GeeksDreamgirl has an interesting take on using Dungeons & Dragon dice to stimulate your musical creativity.
Here’s her take on two of the more important dice:
d8
The d8 is perfect for learning scale degrees and practicing sight-singing.
Your first step is to grab a piece of staff paper and write out the scale you’re going to sight-sing in, [...]

Littlescale demos syncing Nanoloop, a real-time Gameboy sequencer/synth, to Ableton Live:
Part 1

Nanoloop on a Gameboy (whose audio is coming in on track 2) is synchronised to the drums playing in Ableton (track 1). This is to test out a new interface I have been working on that syncs Nanoloop to a MIDI clock.
Part 2

Mario Paint Composer is a remake of the music system from the original Mario Paint for the Super NES. It is a free music application made by unFun Games. It’s available for both Windows and Mac.
It’s a pretty limited app - but that’s part of the [...]