Rolling Stone has a brief article that looks at the music of Spore, and how it’s different than many video games.
In case you’ve been locked in a recording studio - Spore is a new video game that simulates the evolution of creatures from single-cell organisms through the space age. Ambient music artist and superproducer Brian [...]

Last year, we brought you some great video of game creator Will Wright and Brian Eno on generative systems.
Here’s the whole enchilada - their Long Now discussion of Spore and generative music and gaming.
They touch on all sorts of topics, but it includes great discussions of generative processes and ambient music, fractals, compression [...]

Sims designer Will Wright demonstrates the character-creation phase from his latest game, Spore, with additional commentary by musician Brian Eno:

Will Wright and Brian Eno On Generative Systems

Will Wright and Brian Eno On The Spore Metaverse